Impairment of Neutrophil Migration to Remote Inflammatory Site during Lung Histoplasmosis

Figure 3

Effect of SR-27417 and CP-105,696 on PMN numbers in BALF of Hc-infected mice. Hc-infected mice (i.t., 5 × 10⁵ Hc yeast) were pretreated with SR-27417 (0.1 mg/kg) and/or CP-105,696 (1 mg/kg) orally 2 and 16 hours, respectively, before LTB₄ (0.1 μg) injection (in 1 mL PBS) into the air pouch. Vehicle-treated mice received an oral administration of 0.5% CMC or water. BALF was obtained 2 days after Hc infection and PMN numbers determined as described in Materials and Methods. Data are the mean ± SEM of = 6–12. versus vehicle (LTB₄ into air pouch).