High Order Gene-Gene Interactions in Eight Single Nucleotide Polymorphisms of Renin-Angiotensin System Genes for Hypertension Association Study

Table 2

Single-locus analysis of eight SNPs for hypertension and nonhypertension groups.

Loci	Genotypes	HT ()	Non-HT ()	P values
AGT gene
T174M; (rs4762)	CC	243 (77.6%)	106 (81.5%)
	CT	64 (20.4%)	21 (16.2%)	0.303
	TT	6 (1.9%)	3 (2.3%)	0.874
	C : T	7.2 : 1	8.6 : 1
M235T; (rs699)	CC	220 (70.3%)	92 (70.8%)
	CT	84 (26.8%)	38 (29.2%)	0.734
	TT	9 (2.9%)	0 (0.0%)
	C : T	5.1 : 1	5.8 : 1
G-6A; (rs5051)	AA	213 (68.1%)	90 (69.2%)
	AG	88 (28.1%)	40 (30.8%)	0.749
	GG	12 (3.8%)	0 (0.0%)
	A : G	4.6 : 1	5.5 : 1
A-20C; (rs5050)	AA	295 (94.2%)	125 (96.2%)
	AC	15 (4.8%)	3 (2.3%)	0.232
	CC	3 (1.0%)	2 (1.5%)	0.619
	A : C	28.8 : 1	36.1 : 1
G-152A; (rs11568020)	GG	289 (92.3%)	120 (92.3%)
	GA	21 (6.7%)	10 (7.7%)	0.589
	AA	3 (1.0%)	0 (0.0%)
	G : A	22.2 : 1	25.0 : 1
G-217A; (rs5049)	GG	228 (72.8%)	102 (78.5%)
	GA	64 (20.4%)	25 (19.2%)	0.608
	AA	21 (6.7%)	3 (2.3%)	0.057
	G : A	4.9 : 1	7.4 : 1
ACE gene
I/D; (rs4646994)	II	103 (32.9%)	27 (20.8%)
	ID	146 (46.6%)	67 (51.5%)	0.031
	DD	64 (20.4%)	36 (27.7%)	0.010
	I : D	1.3 : 1	0.9 : 1
AT1R gene
A1166C; (rs5186)	AA	287 (91.7%)	115 (88.5%)
	AC	25 (8.0%)	14 (10.8%)	0.339
	CC	1 (0.3%)	1 (0.8%)	0.505
	A : C	22.2	15.3 : 1