Synergistic Activity of Carfilzomib and Panobinostat in Multiple Myeloma Cells via Modulation of ROS Generation and ERK1/2

Figure 1

Coadministration of carfilzomib and LBH589 induced a synergistic inhibition of proliferation in MM cells. (a) All cell lines were incubated for 48 h with carfilzomib and/or LBH589 (low: 2 nM LBH589, 20 nM carfilzomib; intermediate: 4 nM LBH589, 40 nM carfilzomib; and high: 6 nM LBH589, 60 nM carfilzomib) followed by CCK-8 assay. Data represent the mean ± SD for three separate experiments performed in triplicate. . . . ^#. CFZ, carfilzomib. (b) CI values were calculated using median dose effect analysis. CI values < 1.0 denote synergistic interactions.

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