Cardamonin Regulates miR-21 Expression and Suppresses Angiogenesis Induced by Vascular Endothelial Growth Factor
Table 2
Expression levels of miRNAs after cardamonin treatment (means ± SD).
Treatment
miR
Fold change
VEGF
Car
3 h
6 h
24 h
+
−
1.00
1.00
1.00
+
+
miR-17-5p
1.31 ± 0.45
0.96 ± 0.32
0.45 ± 0.10
+
+
miR-19a
0.85 ± 0.15
0.70 ± 0.23
0.32 ± 0.06
+
+
miR-23a
1.88 ± 0.69
0.50 ± 0.12
0.35 ± 0.13
+
+
miR-24
0.75 ± 0.18
0.46 ± 0.17
0.42 ± 0.06
+
+
miR-31
1.33 ± 0.53
0.78 ± 0.12
0.36 ± 0.11
+
+
miR-34a
1.19 ± 0.62
0.50 ± 0.09
0.43 ± 0.07
+
+
miR-126
1.23 ± 0.65
0.55 ± 0.06
0.65 ± 0.20
+
+
miR-130a
0.93 ± 0.48
0.52 ± 0.17
0.72 ± 0.26
+
+
miR-132
1.10 ± 0.59
0.61 ± 0.17
0.39 ± 0.06
+
+
miR-16
1.29 ± 0.61
0.63 ± 0.19
0.37 ± 0.09
+
+
miR-21
1.11 ± 0.62
0.42 ± 0.16
0.29 ± 0.12
Note: and 0.01, respectively, compared with the VEGF group. miRNA level was determined by qRT-PCR after HUVECs were treated with VEGF and cardamonin for 3, 6, and 24 hours. Data was expressed as fold change of VEGF group.
