CF750-A33scFv-Fc-Based Optical Imaging of Subcutaneous and Orthotopic Xenografts of GPA33-Positive Colorectal Cancer in Mice

Figure 4

Tissue distribution of CF750-A33scFv-Fc in mice bearing subcutaneous LS174T xenografts. (a) Optical imaging of the tumor grafts and organ tissues at different time points. Mice () were intravenously injected with CF750-A33scFv-Fc (100 μg) and sacrificed at 5, 9, 24, and 48 h after injection. Tumor grafts and other normal organs/tissues were taken out and scanned using the optical imaging system. (b) The fluorescence intensities of CF750-A33scFv-Fc in the tumor grafts and the organs/tissues at the indicated time points.

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(b)