CF750-A33scFv-Fc-Based Optical Imaging of Subcutaneous and Orthotopic Xenografts of GPA33-Positive Colorectal Cancer in Mice

Figure 5

Optical imaging of mice bearing single SMMC7721 (a), COLO205 (b), or dual LS174T and COLO205 (c) xenografts. Mice () bearing tumor grafts were intravenously injected with CF750-A33scFv-Fc (100 μg) and scanned at 0, 1, 3, and 5 h after injection. SMMC7721, COLO205, and LS174T xenografts are indicated with red circle, blue circle, and red square, respectively. After the last scans (5 h), the mice were sacrificed, and the organs/tissues were removed and scanned. 1: heart, 2: liver, 3: spleen, 4: lung, 5: kidney, 6: muscle, 7: SMMC7721 tumor graft, 8: COLO205 tumor graft, and 9: LS174T tumor graft.

(a)

(b)

(c)