CF750-A33scFv-Fc-Based Optical Imaging of Subcutaneous and Orthotopic Xenografts of GPA33-Positive Colorectal Cancer in Mice

Table 1

Biodistribution of ¹³¹I-A33scFv-Fc in nude mice bearing LS174T xenografts ( at each time point).

Tissue	0.08 h	0.5 h	2 h	5 h	8 h	24 h
Blood	20.98 ± 1.87	10.92 ± 2.43	6.36 ± 1.91	2.86 ± 0.14	1.61 ± 0.28	0.68 ± 0.19
Heart	10.36 ± 2.74	5.47 ± 1.17	3.16 ± 0.90	1.41 ± 0.10	0.81 ± 0.14	0.39 ± 0.15
Liver	10.91 ± 1.80	9.52 ± 1.10	6.53 ± 0.78	3.28 ± 0.21	2.68 ± 0.70	2.12 ± 0.88
Spleen	21.62 ± 3.33	16.63 ± 2.96	9.90 ± 1.31	5.03 ± 0.48	3.23 ± 0.22	2.72 ± 1.28
Lung	35.16 ± 10.71	17.48 ± 2.57	8.56 ± 2.49	3.39 ± 0.34	1.66 ± 0.18	0.73 ± 0.23
Kidney	30.35 ± 2.40	27.14 ± 1.54	20.51 ± 1.46	13.50 ± 0.74	11.48 ± 0.96	7.61 ± 2.19
Stomach	11.59 ± 3.28	16.07 ± 2.32	29.63 ± 9.02	11.93 ± 0.64	4.61 ± 1.18	1.28 ± 0.43
Small intestine	8.82 ± 1.72	6.71 ± 1.03	4.36 ± 2.52	2.86 ± 0.96	2.00 ± 1.44	0.47 ± 0.16
Pancreas	9.96 ± 1.17	7.25 ± 0.60	9.37 ± 3.18	4.38 ± 0.44	1.50 ± 0.32	0.29 ± 0.05
Colon	6.39 ± 1.67	3.79 ± 0.87	5.47 ± 1.37	2.07 ± 0.28	0.95 ± 0.19	0.38 ± 0.11
Brain	1.45 ± 0.02	0.85 ± 0.09	0.81 ± 0.20	0.27 ± 0.02	0.15 ± 0.01	0.03 ± 0.01
Muscle	4.00 ± 0.26	2.47 ± 0.12	2.57 ± 0.41	0.98 ± 0.08	0.62 ± 0.12	0.16 ± 0.05
Tumor	4.28 ± 0.37	4.99 ± 0.06	5.45 ± 1.25	4.21 ± 0.29	2.90 ± 0.37	2.03 ± 0.51

%ID/g: the percent of injected dose per gram tissue.