An Integrated Modeling and Experimental Approach to Study the Influence of Environmental Nutrients on Biofilm Formation of Pseudomonas aeruginosa

Table 3

Biofilm-associated reactions with large flux change upon the change of ferrous ions concentrations (adapted from [9]).

Reactions	Biological subsystems
R 11: 4-maleylacetoacetate → 4-fumarylacetoacetate	Acetate metabolism
R 12: N(omega)-(L-arginino)succinate ↔ L-arginine + fumarate	Arginine metabolism
R 13: ATP + oxaloacetate → ADP + CO2 + phosphoenolpyruvate	Carbon dioxide production
R 14: mg2[e] → mg2[c]	Magnesium transport
R 15: citrate[e] + H^+[e] ↔ citrate[c] + H^+[c]	TCA cycle
R 16: ATP + coenzyme A + succinate ↔ ADP + phosphate + succinyl-CoA	TCA cycle