Triggers, Inhibitors, Mechanisms, and Significance of Eryptosis: The Suicidal Erythrocyte Death

Table 4

Altered eryptosis in gene-targeted mice.

Targeted gene	References
Enhanced eryptosis
GCLM-deficiency	[31]
Annexin 7 deficiency	[216]
Defective hemoglobin (sickle cell, thalassemia)	[205, 206]
cGMP-dependent protein kinase type I (cGKI) deficiency	[217]
AMP-activated protein kinase deficiency	[27]
Klotho deficiency	[218, 219]
EPO excess	[220]
AE1 deficiency	[221]
Reduced eryptosis
PAF receptor deficiency	[133]
Jak3 deficiency	[222]
PDK1 deficiency	[223]
TRPC6 deficiency	[26]