Interleukin 16- (IL-16-) Targeted Ultrasound Imaging Agent Improves Detection of Ovarian Tumors in Laying Hens, a Preclinical Model of Spontaneous Ovarian Cancer

Figure 1

Enhancement of signal intensity of ultrasound imaging of hen ovarian tumors by IL-16-targeted contrast agents. (a) Case 1: precontrast gray scale ultrasonogram of a hen ovary showing solid mass (dotted lines) with septa and accompanied ascites (AS). (b) Postcontrast gray scale ovarian sonogram of the same hen showing enhanced visualization of the solid tumor mass. (c) Case 2: precontrast gray scale sonogram depicting a suspected ovarian mass (dotted lines) in another hen. (d) Gray scale sonogram of the same ovary (shown in (c)), depicting solid tumor mass with enhanced signal intensity after the injection of targeted imaging agents. (e) Gross presentation confirmed the imaging prediction of an ovarian tumor (shown in (c)-(d), appeared as cauliflower-shaped, yellow circled). (f) Histological examination showed a serous malignant tumor with cells containing large pleomorphic nuclei surrounded by a sheath of fibromuscular tissues. H&E staining.

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