Interleukin 16- (IL-16-) Targeted Ultrasound Imaging Agent Improves Detection of Ovarian Tumors in Laying Hens, a Preclinical Model of Spontaneous Ovarian Cancer

Figure 2

Detection of spontaneous ovarian tumors at early stage in hens by IL-16-targeted contrast enhanced ultrasound imaging. (a) Precontrast ovarian sonogram showing low intensity of ultrasound imaging. Presence of tumor-related solid mass in the ovary is inconclusive. (b)-(c) Corresponding contrast enhanced sonogram with enhanced visualization of ultrasound imaging at 5 min and 7 min after the injection of contrast agents, respectively, suggesting the presence of a small solid mass (yellow dotted lines) in the ovary. (d) Gross morphology shows the presence of a tissue mass (yellow dotted line) limited to a part of the ovary accompanied with a little ascites.

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