Interleukin 16- (IL-16-) Targeted Ultrasound Imaging Agent Improves Detection of Ovarian Tumors in Laying Hens, a Preclinical Model of Spontaneous Ovarian Cancer

Figure 3

Changes in the signal intensity of ultrasound imaging by IL-16-targeted contrast agent in the ovary of laying hens with or without ovarian cancer (OVCA). Compared with precontrast imaging, IL-16-targeted contrast agents enhanced the intensities of ultrasound imaging significantly in hens with early stage OVCA as well as in late stage OVCA. However, significant differences were not observed between the pre- and postcontrast imaging in healthy hens. Different letters denote significant differences in the intensities of ultrasound imaging between the pre- and postcontrast imaging within the same group including hens with normal ovaries and with early and late stages of OVCA.