Interleukin 16- (IL-16-) Targeted Ultrasound Imaging Agent Improves Detection of Ovarian Tumors in Laying Hens, a Preclinical Model of Spontaneous Ovarian Cancer

Figure 5

Expression of IL-16 by microvessels in the ovaries of hens with or without ovarian tumors scanned by targeted ultrasound imaging. Top Panel. (A) Section of a normal ovary showing few IL-16 expressing microvessels in the stroma (S). (B) and (C) Sections of malignant ovaries at early (B) and late (C) stages of OVCA. Compared with normal hens (A), more IL-16 expressing microvessels are seen in OVCA hens. S = stroma; arrows indicate examples of IL-16 expressing microvessels. Bottom Panel. Compared with normal hens, the frequency of IL-16 expressing microvessels was significantly () high in OVCA hens at early and late stages. Bars with different letters indicate significant differences in the frequencies of IL-16 expressing microvessels among hens with normal, early stage, and late stage OVCA.