Differential Regulation of MicroRNAs in End-Stage Failing Hearts Is Associated with Left Ventricular Assist Device Unloading

Table 1

Patient characteristics and clinical parameters.

	HTx-CTRL ()	HTx-LVAD ()
		Pre-LVAD	Post-LVAD
Age (years), mean ± SE	52 ± 3	46 ± 4	—
Male gender ()	5	8	—
Duration of LVAD assistance (days), mean ± SE	—	—	357 ± 66
Ischemic heart disease (IHD) ()	2	1	—
Cardiac index (L/min/m^2), mean ± SE	1.90 ± 0.17	1.61 ± 0.13
PCWP (mm Hg), mean ± SE	14 ± 3	24 ± 5	9 ± 3
PASP (mm Hg), mean ± SE	33 ± 4	47 ± 6	27 ± 3
PADP (mm Hg), mean ± SE	13 ± 2		12 ± 4
LVEF (%), mean ± SE	26 ± 2	21 ± 2	28 ± 3
LVESV (mL), mean ± SE	147 ± 17		160 ± 20
LVEDV (mL), mean ± SE	196 ± 18		219 ± 18
LVEDD (mm), mean ± SE	66 ± 2		70 ± 3
NT-proBNP (ng/L), mean ± SE	2976 ± 1562	4800 ± 991	576 ± 145

versus HTx-CTRL; ^‡ versus HTx-CTRL; versus HTx-CTRL; versus pre-LVAD; versus pre-LVAD.
PCWP: pulmonary capillary wedge pressure; PASP: pulmonary artery systolic pressure; PADP: pulmonary artery diastolic pressure; LVEF: left ventricular ejection fraction; LVESV: left ventricular end-systolic volume; LVEDV: left ventricular end-diastolic volume; LVEDD: left ventricular end-diastolic diameter; NT-proBNP: N-terminal prohormone of brain natriuretic peptide.