Differential Regulation of MicroRNAs in End-Stage Failing Hearts Is Associated with Left Ventricular Assist Device Unloading
Table 2
List of differentially expressed (DE) miRNAs in LVAD-supported versus “control” failing explanted hearts.
miRNA
HTx-CTRL
HTx-LVAD
FC
value
adjusted
hsa-miR-29b-3p
5421
3156
0.58
hsa-miR-142-5p
4417
9146
2.07
hsa-miR-4485
3066
329
0.11
hsa-miR-374b-5p
2429
1382
0.57
hsa-miR-4532
2250
833
0.37
hsa-miR-4792
979
412
0.42
hsa-miR-338-3p
936
1536
1.64
hsa-miR-144-5p
873
1465
1.68
hsa-miR-223-3p
669
1947
2.91
hsa-miR-135a-5p
593
161
0.27
hsa-miR-142-3p
498
913
1.83
hsa-miR-335-3p
452
756
1.67
hsa-miR-4284
210
31
0.15
hsa-miR-376a-3p
184
75
0.41
hsa-miR-3195
159
85
0.53
hsa-miR-378g
137
271
1.98
hsa-miR-628-5p
109
193
1.77
hsa-miR-5683
98
415
4.23
hsa-miR-146b-3p
88
251
2.85
hsa-miR-23a-5p
67
119
1.77
hsa-miR-27a-5p
61
126
2.05
hsa-miR-4461
58
118
2.04
hsa-miR-216a-5p
50
8
0.17
Differentially expressed miRNAs are ranked according to the number of read counts. Upregulated and downregulated miRNAs are, respectively, shown in bold and white lines. FC = fold change.
