Differential Regulation of MicroRNAs in End-Stage Failing Hearts Is Associated with Left Ventricular Assist Device Unloading

Table 3

Representative enriched KEGG pathways, involved in heart function or disease, according to in silico analysis of predicted targets of miRNAs associated with clinical parameters in failing heart with/without LVAD support.

KEGG pathway	value	Number of miRNAs	Number of target genes (% in the pathway)
Regulation of actin cytoskeleton		9	29 (13.5%)
Focal adhesion		8	40 (19.3%)
PI3K-Akt signaling pathway		8	50 (14.4%)
mTOR signaling pathway		8	13 (21.7%)
Dilated cardiomyopathy		8	15 (16.7%)
Wnt signaling pathway		8	20 (14.4%)
Hypertrophic cardiomyopathy (HCM)		8	14 (16.9%)
Arrhythmogenic right ventricular cardiomyopathy		8	13 (17.6%)
ECM-receptor interaction		7	23 (26.4%)
MAPK signaling pathway		7	36 (14.0%)
Cytokine-cytokine receptor interaction		7	24 (9.1%)
TGF-beta signaling pathway		6	16 (20.0%)
Adherens junction		6	11 (15.1%)
Phosphatidylinositol signaling system		5	12 (14.8%)