Potential Therapeutic Benefit of Combining Gefitinib and Tamoxifen for Treating Advanced Lung Adenocarcinoma

Figure 1

Kaplan-Meier survival curves demonstrated an overall survival benefit of cytosolic ERβ expression in LAC patients. (a, b) Both nuclear and cytosolic ERα expression revealed no significant difference in overall survival in advanced LAC patients. (c, d) Nuclear ERβ expression exhibited little overall survival benefit in patients. However, cytosolic expression of ERβ exhibited better overall survival in advanced LAC patients (). (e, f) Representative immunohistochemistry staining images of nuclear and cytosolic ERβ in patient number S13-1555 at lower (400x; (e)) and higher (1000x; (f)) magnification. (g, h) Representative immunohistochemistry staining images of cytosolic ERβ in patient number S10-5378 at lower (400x; (g)) and higher (1000x; (h)) magnification.

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