Computational Selection of RNA Aptamer against Angiopoietin-2 and Experimental Evaluation

Figure 3

Analysis of docking results. The docking predictions of aptamer-protein complexes and the amino acid residues involved in the binding interfaces. The locations of red dots indicate the center of the binding interface on the receptor structure for each pose. Amino acids in the Ang2 involved in the binding interaction with each aptamer are detailed, marked with amino acid position numbers. (a) Complex of Ang2/Seq15_12_35. (b) Binding interface between Ang2 and Seq15_12_35. (c) Complex of Ang2/Seq15_15_38. (d) Binding interface between Ang2 and Seq15_15_38.

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