A New Mechanism of Vitamin C Effects on A/FM/1/47(H1N1) Virus-Induced Pneumonia in Restraint-Stressed Mice

Figure 2

Effects of vitamin C on lung inflammation in restraint-stressed mice after infection. (a) Lung index was calculated according to the following formula: lung index = lung weight (mg)/body weight (g). The results represented the mean ± SE of values obtained from 10 mice in each group. (b) Histopathologic changes in lung tissue collected at the 4th day after infection. Representative histological sections of lung tissue from experimental mice were stained by H&E (magnification 400x, bar = 50 μm). N, normal; V, virus; M, model; R, ribavirin; E, edaravone; Vc-L, vitamin C-low dosage; Vc-H, vitamin C-high dosage. Significant differences from the normal group at , the virus group at , and model group at , .

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