Recovering Drug-Induced Apoptosis Subnetwork from Connectivity Map Data

Figure 1

Heat map and PCA plots of drug-perturbed profiles in CMAP of 22,277 informative probe sets. Nonvariant probes across all samples are filtered out by IQR < 0.5. The heat map of distances (a) and the PCA plot (b) between profiles of CMAP data including randomly selected 100 control and 100 drug-perturbed samples.

(a)

(b)