Recovering Drug-Induced Apoptosis Subnetwork from Connectivity Map Data

Figure 2

(a) Top enriched ( < 0.001, FDR < 0.1) GO BP terms by top differentially expressed genes (FDR < 0.05) with apoptosis-related processes highlighted in red; summary of (b) Fisher’s Exact Test and (c) Gene Set Enrichment Analysis (GSEA) to test whether apoptosis pathway with 368 apoptotic genes is enriched in drug-induced signature genes. For GSEA method, absolute mean was used to summarize the enrichment and 10,000 gene permutations were used to produce the significant level.

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