Recovering Drug-Induced Apoptosis Subnetwork from Connectivity Map Data

Figure 6

(a) Predicted subnetwork of 13 selected drug-responsive apoptotic genes: edges in red are validated interactions in literature and edges in dark red are strong validated direct interactions. (b) A subnetwork from literature showing evidences for validated interactions in predicted network including candidate genes (colored in yellow) with their validated interactants (in brown). Each validated edge in predicted network (red in (a)) can be mapped to one path in evidence network (b) between the two corresponding interacting candidate genes.

(a)

(b)