Recovering Drug-Induced Apoptosis Subnetwork from Connectivity Map Data
Table 1
The 13 selected differentially expressed or drug-responsive apoptotic genes.
Gene symbol
probeId
entrezId
value
FDR
Apoptosis type*
PMAIP1
204285_s_at
5366
0.32
7.46
pro
VEGFA
210512_s_at
7422
0.18
6.15
anti
SERINC3
221471_at
10955
0.06
5.62
pro
TNFAIP3
202644_s_at
7128
0.24
5.39
anti
BNIP3L
221479_s_at
665
0.12
5.04
both
GCLC
202923_s_at
2729
0.08
4.91
anti
BCL2L11
222343_at
10018
0.14
4.83
pro
TAX1BP1
200976_s_at
8887
0.07
4.76
anti
SON
214988_s_at
6651
−0.06
−4.75
anti
NUP62
202153_s_at
23636
−0.11
−4.83
anti
NOL3
59625_at
8996
−0.13
−5.32
anti
TUBB
212320_at
203068
−0.09
−5.55
pro
MSH6
202911_at
2956
−0.09
−6.40
pro
pro: annotated by GO terms: induction of apoptosis, positive regulation of apoptosis, and negative regulation of antiapoptosis; anti: annotated by GO terms: negative regulation of apoptosis and positive regulation of antiapoptosis.
