Anemia in Inflammatory Bowel Disease Outpatients: Prevalence, Risk Factors, and Etiology
Table 1
Demographic and clinical characteristics of the inflammatory bowel disease patients with and without anemia.
Crohn’s disease
Ulcerative colitis
Total
Anemia
No anemia
Anemia
No Anemia
Anemia
No anemia
Total (%)
24 (24)
76 (76)
18 (18)
82 (82)
42 (21)
158 (79)
Gender (%)
Female
11 (17.2)
53 (82.8)
11 (18)
50 (82)
22 (17.6)
103 (82.4)
Male
13 (36.1)
23 (63.9)
07 (17.9)
32 (82.1)
20 (26.7)
55 (73.3)
Age, year (median/range)
38.9 (18–64)
42.2 (19–63)
41.1 (20–64)
45.6 (19–65)
41.1 (18–64)
43.9 (19–65)
Disease activity∗ (%)
In remission
17 (19.5)
70 (80.5)
7 (14.6)
41 (85.4)
24 (17.8)
111 (82.2)
Mild
4 (50)
4 (50)
6 (13.3)
39 (86.7)
10 (18.9)
43 (81.1)
Moderate
3 (60)
2 (40)
5 (71.4)
2 (28.6)
8 (66.7)
4 (33.3)
CD location (%)
Ileal
8 (34.8)
15 (65.2)
Colonic
7 (20.6)
27 (79.4)
Ileocolonic
9 (20.9)
34 (79.1)
UC location (%)
Ulcerative proctitis
8 (15.1)
45 (84.9)
Left sided UC
2 (10)
18 (90)
Extensive UC
8 (29.6)
19 (70.4)
Behavior of CD (%)†
B1
8 (21.6)
29 (78.4)
B2
7 (25)
21 (75)
B3
9 (25.7)
26 (74.3)
Disease duration (year) (median/range)
6.4 (1.4–12.8)
8 (0.8–11.6)
7.4 ± 7.3 (2.7–10.8)
7.7 ± 5.2 (1–11)
6.8 ± 7.0 (1.4–12.8)
7.8 ± 6.2 (0.8–11.6)
Previous surgery (%)
Yes
9 (23.1)
30 (76.9)
1 (50)
1 (50)
10 (24.4)
31 (75.6)
No
15 (24.6)
46 (65.4)
17 (17.3)
81 (82.7)
32 (20.1)
127 (79.9)
Smoking∗∗ (%)
Yes
2 (11.1)
16 (88.9)
1 (5.9)
16 (94.1)
3 (8.6)
32 (91.4)
No
22 (26.8)
60 (73.2)
17 (20.5)
66 (79.5)
39 (23.6)
126 (76.4)
CRP∗∗∗ (mg/L) (median/range)
12.9 (1–80)
4.6 (1–45)
9.9 (1–60)
4.9 (1–30)
11 (1–80)
3.5 (1–45)
CD: Crohn’s disease; UC: ulcerative colitis; CRP: C-reactive protein. ∗For moderate disease activity there was a statistically significant difference with P = 0.024 (CD), P = 0.001 (UC), and P < 0.001 (for total population). ∗∗For smoking there was a statistically significant difference with P = 0.047 (for total population). ∗∗∗For CRP there was a statistically significant difference with P < 0.001 (CD) and P = 0.009 (UC).
#For all other characteristics, there was no significant difference. †B1: nonstricturing, nonpenetrating; B2: stricturing; B3: penetrating.
