A Comparison of the Process of Remodeling of Hydroxyapatite/Poly-D/L-Lactide and Beta-Tricalcium Phosphate in a Loading Site

Figure 10

Tissue sections were stained for cathepsin K and viewed at ×200 magnification. ((a), (c), and (e)) TCP group. ((b), (d), and (f)) HP group. ((a), (b)) 1 month. ((c), (d)) 3 months. ((e), (f)) 12 months. (g) Number of osteoclast-like cells present after implantation of bioresorbable materials. β-TCP (grey box), HA/PDLLA (black box). The number of cathepsin K-positive cells was measured. We defined osteoclast-like cells as cells that were cathepsin K-positive and possessed more than five nuclei. HP groups showed significantly more osteoclast-like cells compared to the TCP groups during the follow-up period. In the HP group, the positive cells reduced significantly over time. In the TCP group, the 3-month group showed a significant more cathepsin K-positive cells compared to the 1- and 12-month groups. : versus TCP group. †: versus 1 month. §: versus 3 months. Scale bars: 100 µm.