The Diagnosis Value of Promoter Methylation of UCHL1 in the Serum for Progression of Gastric Cancer

Table 2

Methylation level of four genes in the serum of age-matched controls, CAG patients, and GC patients.

Gene

Methylation level (mean ± SD)

value

Controls

CAG

GC

Overall

Controls versus CAG

Controls versus GC

CAG versus GC

FLNC

0.082 ± 0.063

0.147 ± 0.184

0.849 ± 1.100

0.005

0.309

0.002

0.019

THBS1

0.051 ± 0.039

0.058 ± 0.049

0.836 ± 1.118

<0.001

0.259

<0.001

<0.001

UCHL1

0.041 ± 0.023

0.044 ± 0.010

0.549 ± 0.614

<0.001

0.08

<0.001

0.016

DLEC1

0.189 ± 0.065

0.203 ± 0.073

0.989 ± 0.767

0.012

0.662

0.005

0.033

SD, standard deviation; GC, gastric cancer; CAG, chronic atrophic gastritis; value calculated by nonparametric Kruskal-Wallis test; value calculated by Bonferroni correction.