Research Article
The Diagnosis Value of Promoter Methylation of UCHL1 in the Serum for Progression of Gastric Cancer
Table 4
Correlations between clinicopathological features and methylation status of genes in GC patients.
| | Variables | GC patients | FLNC | THBS1 | UCHL1 | DLEC1 | | M (%) | | M (%) | | M (%) | | M (%) | |
| | Age (years) | | | 0.953 | | 0.021 | | 0.429 | | 0.396 | | <60 | 28 (34) | 18 (64) | | 13 (46) | | 14 (50) | | 24 (86) | | | ≥60 | 54 (66) | 37 (69) | | 39 (72) | | 32 (60) | | 42 (78) | | | H. pylori infection | | | 0.009 | | 0.106 | | 0.065 | | 0.747 | | No | 38 (46) | 20 (53) | | 22 (58) | | 20 (53) | | 30 (79) | | | Yes | 44 (54) | 35 (80) | | 30 (68) | | 26 (59) | | 36 (81) | | | Tumor size (cm) | | | 0.185 | | 0.797 | | 0.974 | | 0.040 | | <3 | 34 (42) | 20 (59) | | 21 (62) | | 19 (56) | | 28 (82) | | | ≥3 | 48 (58) | 35 (73) | | 31 (65) | | 27 (56) | | 38 (79) | | | Differentiation | | | 0.016 | | 0.223 | | 0.305 | | 0.766 | | Good/moderate | 54 (66) | 35 (65) | | 35 (65) | | 31 (57) | | 47 (87) | | | Poor | 28 (34) | 20 (71) | | 17 (61) | | 15 (54) | | 19 (68) | | | TNM Stage | | | 0.131 | | 0.262 | | 0.026 | | 0.361 | | I, II | 48 (59) | 29 (60) | | 28 (58) | | 22 (46) | | 37 (77) | | | III, IV | 34 (41) | 26 (76) | | 24 (71) | | 24 (71) | | 29 (85) | | | Lymph node metastasis | | | 0.233 | | 0.854 | | 0.014 | | 0.705 | | N0 | 29 (35) | 17 (59) | | 18 (62) | | 11 (38) | | 24 (83) | | | N1–3 | 53 (65) | 38 (72) | | 34 (64) | | 35 (66) | | 42 (79) | |
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M, methylation, (%); value calculated by Fisher’s exact test; values < 0.05 are presented in bold.
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