Research Article
Diagnostic Value of MRI Proton Density Fat Fraction for Assessing Liver Steatosis in Chronic Viral C Hepatitis
Table 1
Characteristics of patients and results of histological analysis of liver biopsy specimens.
| | Characteristics of patients | Proportions, means ± standard deviation | Percentages, medians, and range |
| | Males | 43/77 | 55.8% | | Females | 34/77 | 44.2% | | Age | 51.31 ± 11.27 | 51 (18–81) | | BMI | 22.39 ± 2.27 | 23 (18.43–27) | | Serum AST level (U/L) | 66.49 ± 65.93 | 48 (18–293) | | Serum ALT level (U/L) | 62.83 ± 53.13 | 51 (15–302) | | Serum GGT level (U/L) | 92.63 ± 90.92 | 62 (11–368) | | Total bilirubin (mg/dL) | 1.05 ± 1.26 | 0.7 (0.2–9) | | Platelet count (103 cells/µL) | 196.25 ± 62.06 | 199 (99–462) | | Serum ferritin level (ng/mL) | 167.43 ± 141.68 | 134.3 (13.3–700.4) | | HCV-RNA (IU/mL) | 1.96 × 106 ± 1.91 × 106 | 1.34 × 106 (2.99 × 103–6.65 × 106) | | Stiffness (kPa) | 12.86 ± 11.57 | 7.2 (3.8–55) |
| | Histology | | Histological fat fraction | 9.09 ± 12.68 | 3 (0–45) |
| | Steatosis grade (S) | | Grade 0 (<5%) | 46/77 | 59.7% | | Grade 1 (5–33%) | 23/77 | 29.9% | | Grade 2 (33–66%) | 8/77 | 10.4% | | Grade 3 (>66%) | 0/77 | 0% |
| | Necroinflammation (A) | | Grade 0 | 25/77 | 32.5% | | Grade 1 | 33/77 | 42.8% | | Grade 2 | 14/77 | 18.2% | | Grade 3 | 5/77 | 6.5% |
| | Fibrosis (F) | | F0 (none) | 23/77 | 29.9% | | F1 (perisinusoidal or periportal) | 14/77 | 18.2% | | F2 (perisinusoidal and portal/periportal) | 12/77 | 15.5% | | F3 (bridging fibrosis) | 18/77 | 23.4% | | F4 (cirrhosis) | 10/77 | 13% |
| | Histologically detectable iron | | Grade 0 | 73/77 | 94.8% | | Grade 1 | 2/77 | 2.6% | | Grade 2 | 2/77 | 2.6% | | Grade 3 | 0/77 | 0% |
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Values are expressed as percentages, means ± standard deviation, and medians (min–max).
Legend: BMI, body mass index.
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