Nitric Oxide Protects L-Type Calcium Channel of Cardiomyocyte during Long-Term Isoproterenol Stimulation in Tail-Suspended Rats

Figure 4

I-V curves in left ventricular cardiomyocyte of CON and SUS rats. (a) I-V curves of the CON and 4 wk SUS groups with or without 1 μM of ISO stimulation. (b) The increasing percentage of peak with 1 μM of ISO treatment for 10 min. (c) I-V curves of LTCC with or without 240 nM nNOS inhibitor (NAAN). (d) I-V curves of LTCC with or without 240 nM NAAN + 1 μM ISO treatment. (e) I-V curves of LTCC with or without 100 μM NO donor (SNAP) treatment. (f) I-V curves of LTCC with or without 100 μM SNAP + 1 μM ISO treatment. (g) Maximal of I-V curves with different treatments. (h) Ratios of peak at the 50th min with ISO treatment to that at the 10th min. Data are mean ± SEM; cardiomyocytes from 5 hearts in each treatment. and versus CON vehicle. and versus CON with ISO treatment. and versus the value at the 10th min.

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