Nitric Oxide Protects L-Type Calcium Channel of Cardiomyocyte during Long-Term Isoproterenol Stimulation in Tail-Suspended Rats

Figure 7

Properties of LTCC recovery in cardiomyocytes of 4-week tail-suspended and control rats. (a) Protocol for LTCC recovery and representative evoked currents. (b) Recovery curves of LTCC with or without 1 μM ISO treatment. (c) Recovery curves of LTCC with or without 240 nM NAAN. (d) Recovery curves of LTCC with or without 240 nM NAAN + 1 μM ISO treatment. (e) Recovery curves of LTCC with or without 100 μM SNAP treatment. (f) Recovery curves of LTCC with or without 100 μM SNAP + 1 μM ISO treatment. (g) values of recovery curves with different treatments in CON and 4 wk SUS groups. is a time constant which indicates the recovery rate of inactivated LTCC. (h) Ratios at the end of recovery. Data are mean ± SEM; cardiomyocytes from 5 hearts. and versus CON vehicle. versus CON with ISO treatment.

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