The Skin as an Early Expression of Malignancies in the Neonatal Age: A Review of the Literature and a Case Series

Figure 2

Lesions in a male neonate with Down syndrome, affected by TMD. Gradually, we observed evolution of the skin lesion, such as vesiculopustular eruption on the face (a) and vesiculopustular eruption on arm (b). A biopsy of the lesions showed mild acanthosis epidermis that was focally eroded. Within the superficial dermis and extending into the epidermis were large mononuclear cells with hyperchromatic nuclei and abundant eosinophilic cytoplasm consistent with immature myeloid cells. Immunohistochemical stains showed strong immunoreactivity of these cells with myeloperoxidase and a megakaryocytic cell marker LAT (linker for activation of T cells), confirming that the cells were of myeloid and megakaryoblastic origin (Figure 3). The histologic findings supported the clinical suspicion of a TMD.

(a)

(b)