Exercise-Induced Neuroprotection in the Spastic Han Wistar Rat: The Possible Role of Brain-Derived Neurotrophic Factor

Figure 3

Photomicrographs of cerebellums from normal animals treated with (a) DMSO (vehicle) or (b) K252a and mutant animals treated with (c) DMSO or (d) K252a. All animals were subjected to a 28-day running regimen. Note the slight loss of Purkinje cells in mutant (c) (DMSO-treated) compared to the significant loss in the K252a treated mutants (d). Arrows indicate surviving Purkinje cells. Scale bar in the lower right panel refers to all photos (50 μm at 200x magnification).

(a)

(b)

(c)

(d)