Exercise-Induced Neuroprotection in the Spastic Han Wistar Rat: The Possible Role of Brain-Derived Neurotrophic Factor

Figure 5

TrkB expression in the cerebellums of acutely exercised (7 days), chronically exercised (30-day run), and their sedentary (Sdty) mutant and normal controls ( per training regimen and genotype). Three-way ANOVA showed a significant interaction of genotype exercise treatments (). Significant increases in TrkB expression were observed in acute runners compared to their sedentary counterparts (^*). In the chronically treated group, the genotype (^**) had a greater effect on TrkB expression than running treatment (). A synergistic effect of running and genotype (normal) on TrkB expression was found in the chronically treated group (^*) and -axis values were based on a scoring intensity ranking of TrkB immunostaining. Values are mean SEM.