Research Article
How to Choose In Vitro Systems to Predict In Vivo Drug Clearance: A System Pharmacology Perspective
Table 3
Scaling factor with different enzymes and expression systems.
| | Enzymes | Expression systems | Scaling factor (mean SD) | CV |
| | 1A2 | Baculovirus | 1.493 1.112 | 74.48% | | 1A2 | E. coli | −0.869 | — | | 1A2 | Lymphoblastoid | −1.154 | — | | 1A2 | Yeast | 3.794 | — | | 2B6 | Baculovirus | 2.232 3.756 | 168.28% | | 2C8 | Baculovirus | 2.093 2.588 | 123.65% | | 2C9 | Baculovirus | 0.947 3.490 | 368.53% | | 2C9 | E. coli | 5.828 | — | | 2C9 | Lymphoblastoid | 1.530 2.351 | 153.66% | | 2C9 | Yeast | 1.894 | — | | 2C19 | Baculovirus | −1.735 1.716 | 98.90% | | 2C19 | Lymphoblastoid | 1.181 | — | | 2D6 | Baculovirus | 2.394 0.601 | 25.10% | | 2D6 | Lymphoblastoid | 1.213 0.790 | 65.13% | | 2D6 | E. coli | 7.290 | — | | 2D6 | Yeast | 2.399 2.111 | 87.95% | | 3A | Baculovirus | −1.320 2.653 | 200.98% | | 3A | E. coli | −1.014 | — | | 3A | Lymphoblastoid | 0.993 3.541 | 356.60% | | 3A | Yeast | 1.038 | — |
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