Gender-Specific Associations of Serum Antibody to Porphyromonas gingivalis and Inflammatory Markers
Table 1
Characteristics of study subjects in 2003 and 2011.
Variables
2003
2011
Males ( = 295)
Females ( = 116)
All
value
Males ( = 295)
Females ( = 116)
All
value
The number of the present teeth (median 25%, 75%)
27 (24, 28)
26 (21, 28)
26 (23, 28)
0.001
26 (22, 28)
24 (20, 27)
25 (22, 28)
0.003
Periodontal disease (PD ≥ 4 mm) (%)
48.5
44.8
47.4
0.505
52.5
33.6
47.2
0.001
Serum antibody titer against
7.7 (3.3, 15.6)
8.6 (3.5, 21.8)
7.9 (3.4, 17.0)
0.363
Age (median 25%, 75%)
57 (48, 68)
60 (50, 69)
57 (49, 68)
0.166
65 (56, 76)
68 (58, 77)
65 (57, 76)
0.158
More than 3 times daily toothbrushing
28.1
50.0
34.3
<0.001
Current/past smoking (%)
63.7
3.4
46.7
<0.001
63.7
3.4
46.7
<0.001
Current alcohol consumption (%
76.3
37.1
65.2
<0.001
69.5
29.8
58.4
<0.001
Overweight (%)
30.2
21.6
27.7
0.079
28.8
27.6
28.5
0.804
Elevated hsCRP (≥1 mg/L) (%
18.6
17.2
18.2
0.740
Elevated fasting glucose (≥100 mg/dL) (%)
62.2
51.7
59.4
0.048
55.9
37.9
50.9
0.001
Reduced HDL (males < 40, females < 50 mg/dL) (%
3.7
5.2
4.1
0.508
1.4
2.6
1.7
0.386
Elevated triglycerides (≥150 mg/dL) (%
32.9
25.0
30.7
0.119
33.6
37.9
34.8
0.402
Elevated blood pressure (≥130/≥85 mmHg) (%
34.6
25.9
32.1
0.089
29.8
16.4
26.0
0.005
Elevated leukocytes (≥9.0 109 cells/L) (%)
4.4
0
3.2
0.024
1.4
0
1.0
0.581
Leukocytes (median 25%, 75%) (109 cells/L)
5.5 (4.7, 6.6)
5.2 (4.5, 6.0)
5.4 (4.6, 6.3)
0.003
5.1 (4.3, 6.0)
4.7 (4.1, 5.5)
5.0 (4.3, 5.8)
0.007
Neutrophils (median 25%, 75%) (109 cells/L)
3.2 (2.6, 3.9)
3.0 (2.5, 3.6)
3.1 (2.6, 3.8)
0.038
3.0 (2.4, 3.5)
2.7 (2.1, 3.3)
2.9 (2.3, 3.5)
0.013
Acidocytes (median 25%, 75%) (109 cells/L)
0.19 (0.01, 0.25)
0.12 (0.08, 0.20)
0.15 (0.09, 0.24)
0.003
0.13 (0.08, 0.23)
0.10 (0.06, 0.18)
0.13 (0.08, 0.21)
<0.001
Monocytes (median 25%, 75%) (109 cells/L)
0.31 (0.25, 0.37)
0.26 (0.22, 0.31)
0.30 (0.24, 0.36)
<0.001
0.29 (0.24, 0.36)
0.24 (0.21, 0.29)
0.28 (0.23, 0.34)
<0.001
Serum antibody titer against and hsCRP were measured in preserved serum samples in 2003. Males, = 292; females, = 114, in 2011. HDL < 40 mg/dL in males and <50 mg/dL in females for reduced HDL. Triglycerides ≥ 150 mg/dL or drug treatment for dyslipidemia. Systolic blood pressure ≥130 mmHg or diastolic blood pressure ≥85 mmHg or antihypertensive drug treatment. PD, periodontal pocket depth; hsCRP, high-sensitive C-reactive protein; HDL, high-density lipoprotein cholesterol.
