Protection against Multiple Subtypes of Influenza Viruses by Virus-Like Particle Vaccines Based on a Hemagglutinin Conserved Epitope

Figure 3

Survival rates (a) and body weight changes (b) after challenge with the mouse-adapted A/PR/8/34 (H1N1) (5 × LD₅₀) in mice (10 mice in each group) immunized with LAH-HBc vaccine in combination with or without CTB^*, three times at an interval of 2 weeks. Mice were challenged 3 weeks after the last immunization. The survival rates and body weights of the mice were measured daily from the date of the challenge to 21 days after the challenge. ^*Significant difference compared to the control group ().

(a)

(b)