Protection against Multiple Subtypes of Influenza Viruses by Virus-Like Particle Vaccines Based on a Hemagglutinin Conserved Epitope

Figure 5

Detection of IFN-γ secreted by lymphocyte in spleen. Mice (3 mice in each group) were immunized with LAH-HBc vaccine as described in Table 1. Three weeks after the last immunization, splenocytes were harvested and stimulated with LAH-HBc (a) or HA A/California/07/2009 (H1N1) (b). ^*Significant difference ().

(a)

(b)