Research Article

Protection against Multiple Subtypes of Influenza Viruses by Virus-Like Particle Vaccines Based on a Hemagglutinin Conserved Epitope

Table 4

Sequence identities of the HA2 76-130aa between A/PR/8/34 (H1N1) and the tested heterologous influenza A virus.

Influenza strainIdentitiesSurvival mice/tested miceThe maximum rate of weight loss

A/California/07/2009 (H1N1)52/55 (94.5%)10/10 (100%)7.2%
A/Vietnam/1194/2004 (H5N1)45/55 (81.8%)6/10 (60%)27.1%
A/Chicken/Jiangsu/7/2002 (H9N2)35/55 (63.6%)10/10 (100%)18.8%