Research Article

Patients with Intolerance Reactions to Total Knee Replacement: Combined Assessment of Allergy Diagnostics, Periprosthetic Histology, and Peri-implant Cytokine Expression Pattern

Figure 2

(a) Histology of patch test (PT) reaction to Ni showing perivascular T-lymphocytic infiltrates, scattered eosinophils, and epidermal “spongiotic” changes. (b) Relative inflammatory mediator expression in biopsy of positive PT reaction to Ni. Analysis based on semiquantitative real-time RT-PCR.
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