Patients with Intolerance Reactions to Total Knee Replacement: Combined Assessment of Allergy Diagnostics, Periprosthetic Histology, and Peri-implant Cytokine Expression Pattern

Table 3

Patch test/LTT results and histology grading, Group II.

Patient number	Age, sex	Patch test reaction	LTT-reaction	CD3-infiltrate		KP1	CD20	CD15	Rating (Type I–IV according to [24])
				Qualitative	Quantitative
11	61, m	neg	Ni	Diffuse	−	+	−	−	Type 4
12	65, f	neg	Ni	Diffuse	−	++	−	−	Type 1
14	66, m	neg	Ni, Co	Diffuse	−	++	−	−	Type 4
2	71, m	neg	Ni	Diffuse	+	++	+	−	Type 1
4	66, m	neg	Ni	Diffuse	+	+	−	−	Type 4
5	64, m	neg	Ni	Diffuse	+	+	−	−	Type 4
6	53 m	neg	Ni	Diffuse	+	++	−	−	Type 4
13	69, m	neg	Ni	Diffuse	+	−	−	−	Type 4
20	63, f	neg	Ni	Diffuse	+	++	−	+	Type 1

Findings in 9 patients with CoCrMo based knee arthroplasty with complications, negative patch test but positive lymphocyte transformation test (LTT); abbreviations see Table 2.