Patients with Intolerance Reactions to Total Knee Replacement: Combined Assessment of Allergy Diagnostics, Periprosthetic Histology, and Peri-implant Cytokine Expression Pattern

Table 4

Patch test/LTT results and histology grading, group III.

Patient number	Age, sex	Patch test reaction	LTT-reaction	CD3-infiltrate		KP1	CD20	CD15	Rating (Type I–IV according to [24])
				Qualitative	Quantitative
IAR 6	59, f	neg	Neg	−	−	−	−	−	n.a.^*
IAR 18	73, f	neg	Neg	−	−	−	−	−	Type 4
IAR 23	74, f	neg	Neg	−	−	−	−	−	Type 4
IAR 26	68, m	neg	Neg	−	−	−	−	+	Type 2
IAR 5	75, m	neg	Neg	Focal	+++	+++	+++	+++	Type 2

n.a.: not applicable because of fibrinoid necrosis.
Findings in 5 patients with CoCrMo based knee arthroplasty with complications, negative patch test, and negative LTT; for abbreviations see Table 2.