Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous Transplant
Table 3
Parameters analyzed for relapse adjusted by different prognostic factors.
Variable
Patients
Group A with EIa ()
Group B without EI ()
Crude relative risk
No relapse
Relapse
No relapse
Relapse
(%)
(%)
(%)
(%)
CRR × Sb (CI 95%)
RRAMHc (CI 95%)
Age (years)
<10
10 (90.9)
1 (9.1)
7 (58.3)
5 (41.7)
0.22 (0.03–1.59)
>10
8 (88.9)
1 (11.1)
5 (62.5)
3 (37.5)
0.30 (0.04–2.31)
0.25
(0.06–1.11)
Sex
Female
8 (88.9)
1 (11.1)
9 (100)
0 (0.0)
2.00 (0.21–18.98)
Male
10 (90.9)
1 (9.1)
3 (27.3)
8 (72.7)
0.22 (0.06–0.84)
0.40
(0.14–1.11)
Leukocytes
<50 000/L
15 (100)
0 (0.0)
10 (62.5)
6 (37.5)
0.15 (0.20–1.10)
>50 000/L
3 (60.0)
2 (40.0)
2 (50.0)
2 (50.0)
1.14 (0.40–3.18)
0.47
(0.18–1.18)
BMd Day 15
<5% blasts
11 (91.7)
1 (8.3)
10 (71.4)
4 (28.6)
0.29 (0.37–2.26)
>5% blasts
7 (87.5)
1 (12.5)
2 (33.3)
4 (66.7)
0.18 (0.02–1.27)
0.23
(0.05–0.94)
Risk
Low
3 (100)
0 (0.0)
3 (100)
0 (0.0)
1.00 (0.08–11.9)
High
15 (88.2)
2 (11.8)
9 (52.9)
8 (47.1)
0.33 (0.10–1.04)
0.40
(0.14–1.10)
Time of CRe
<8 weeks
14 (93.3)
1 (6.7)
9 (64.3)
5 (35.7)
0.18 (0.02–1.40)
>8 weeks
4 (80.0)
1 (20.0)
3 (50.0)
3 (50.0)
0.40 (0.59–2.74)
0.26
(0.06–1.04)
CTf for CR
One cycle
11 (91.7)
1 (8.3)
10 (66.7)
5 (33.3)
0.25 (0.03–1.86)
Two cycles
7 (87.5)
1 (12.5)
2 (40.0)
3 (60.0)
0.20 (0.02–1.49)
0.23
(0.05–0.95)
CR upon APBTg,h
>10 months
9 (90.0)
1 (10.0)
4 (57.1)
3 (42.9)
0.37 (0.87–1.61)
<10 months
9 (100)
0 (0.0)
8 (61.5)
5 (38.5)
0.15 (0.02–1.14)
0.26
(0.82–0.83)
MNCh,i (108/kg)
<5
14 (93.3)
1 (6.7)
8 (66.7)
4 (33.3)
0.32 (0.07–1.44)
>5
4 (100)
0 (0.0)
4 (50.0)
4 (50.0)
0.33 (0.10–1.06)
0.33
(0.10–1.06)
CD34+ cellsh (106/kg)
>3
3 (100)
0 (0.0)
3 (60.0)
2 (40.0)
0.46 (0.06–3.23)
<3
15 (93.8)
1 (6.3)
9 (60.0)
6 (40.0)
0.26 (0.06–1.12)
0.32
(0.10–1.00)
EI: early intensification.
bCRR × S: crude relative risk by strata.
cCR (MH): relative risk, adjusted (Mantel-Haenszel).
dBM: bone marrow.
eCR: complete remission.
fCT: chemotherapy.
gAPBT: autologous peripheral blood transplant.
hOnly 19 patients in Group A received transplant (see text for details).
iMNC: mononuclear cell.
