Shengmai Injection Improved Doxorubicin-Induced Cardiomyopathy by Alleviating Myocardial Endoplasmic Reticulum Stress and Caspase-12 Dependent Apoptosis

Figure 4

The expressions of GRP78 and caspase-12 cross all the groups: (a) GRP78 mRNA expression, (b) caspase-12 mRNA expression, (c) GRP78 protein expression, and (d) caspase-12 protein expression. At the end of follow-up duration, there were 20 survivals in control group, 11 in DOX group, and 16 in DOX + SMI group, respectively. Compared to control group, ; compared to DOX group, .

(a)

(b)

(c)

(d)