Comparison of Monkeypox Virus Clade Kinetics and Pathology within the Prairie Dog Animal Model Using a Serial Sacrifice Study Design

Figure 4

Monkeypox viral trafficking within prairie dogs. Groups of prairie dogs were serially sacrificed (days 2, 4, 6, 9, 12, 17, and 24) following intranasal challenge (8 × 10³ p.f.u.) with West African (blue) or Congo Basin (green) MPXV. Samples were evaluated for the presence of virus by tissue culture. The time courses of viral shedding from each tissue type are shown above.