Comparison of Monkeypox Virus Clade Kinetics and Pathology within the Prairie Dog Animal Model Using a Serial Sacrifice Study Design

Figure 5

Schematic depicting CB MPXV disease progression in a prairie dog. Groups of prairie dogs were intranasally challenged (8 × 10³ p.f.u.) with Congo Basin (CB) MPXV. Groups of prairie dogs were serially sacrificed (days 2, 4, 6, 9, 12, 17, and 24) following challenge. Samples were evaluated for the presence of virus and were grouped by initial detection of viable virus (day 4 (a), 6 (b), 9 (c), or 12 (d) p.i.).

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