Does Citrulline Have Protective Effects on Liver Injury in Septic Rats?
Table 4
Serum concentrations of cytokines and chemokines in each group (pg/mL).
Analyte
Normal group
Cit group
CLP group
CLP+Cit group
6 h
12 h
24 h
6 h
12 h
24 h
G-CSF
Undetected
Undetected
8.75 ± 2.38
13.59 ± 2.01▲
13.08 ± 0.08
4.72 ± 3.92
4.03 ± 1.62
21.38 ± 0.71▲
Eotaxin
6.65 ± 2.83
3.78 ± 1.57
14.89 ± 4.78▲
12.24 ± 7.88
10.49 ± 2.99
12.22 ± 2.59
12.46 ± 5.30
17.35 ± 4.95▲
GM-CSF
Undetected
Undetected
98.58 ± 92.66
105.45 ± 86.76▲
72.70 ± 22.15
82.70 ± 53.41▲
63.39 ± 36.31
49.49 ± 23.77
IL-1α
3.10 ± 2.19
Undetected
55.67 ± 26.83▲
23.86 ± 9.70
41.49 ± 24.61
53.31 ± 48.32▲
26.85 ± 22.37
51.55 ± 21.02
Leptin
2810.2 ± 1184.97
2123.75 ± 699.71
20809.5 ± 7712.10▲
15190.6 ± 7086.61
6007.75 ± 4217.84
8735.2 ± 1996.72
9794 ± 5442.86
18706.6 ± 13241.32▲
MIP-1α
32.67 ± 11.55
26.36 ± 3.51
513.14 ± 287.45▲
127.97 ± 87.43
36.86 ± 12.72
205.86 ± 88.74
183.71 ± 193.66
251.80 ± 196.25▲
IL-4
Undetected
Undetected
29.49 ± 22.55▲
19.71 ± 20.95
8.18 ± 12.72
24.60 ± 11.00
31.65 ± 21.72
39.54 ± 19.73▲
IL-1β
49.28 ± 42.19
44.16 ± 14.61
652.95 ± 54.49▲
371.35 ± 289.02
301.4 ± 234.89
233.07 ± 45.24
152.92 ± 117.18
278.02 ± 185.33▲
IL-2
37.92 ± 17.30
25.92 ± 6.67
170.84 ± 75.04▲
71.37 ± 68.65
65.11 ± 25.37
63.95 ± 33.33
94.15 ± 2.50▲
92.90 ± 63.45
IL-6
120.95 ± 25.71
64.18 ± 43.70
30070 ± 20440.72▲
1954.90 ± 923.72
1293.21 ± 934.89
2097.75 ± 2727.34
1688.46 ± 1826.3
21660.26 ± 27160.17▲
EGF
0.71 ± 0.177
Undetected
2.22 ± 0.35▲
1.13 ± 1.88
1.59 ± 1.33
0.11 ± 0.08
0.85 ± 1.21
1.40 ± 1.33▲
IL-13
19.14 ± 3.90
10.29 ± 5.82
22.72 ± 12.89
22.83 ± 9.28▲
15.98 ± 3.83
24.38 ± 4.70
20.37 ± 9.06
31.31 ± 13.92▲
L-10
53.06 ± 23.80
62.83 ± 28.28
2254.67 ± 1025.29▲
2067.44 ± 2493.23
502.68 ± 208.96
321.36 ± 65.49
725.92 ± 613.66
2459.21 ± 1949.54▲
IL-12(p70)
77.31 ± 22.39
77.80 ± 0.76
193.73 ± 124.92▲
148.91 ± 88.35
58.43 ± 64.20
111.88 ± 34.80
108.50 ± 47.57
168.61 ± 56.16▲
IFN-γ
56.042 ± 23.74
43.32 ± 15.73
125.1 ± 52.58▲
102.26 ± 42.89
85.74 ± 37.04
87.24 ± 39.86
98.87 ± 52.01
120.82 ± 57.06▲
IL-5
58.71 ± 21.54
50.30 ± 18.33
127.96 ± 30.39
132.35 ± 28.57▲
107.46 ± 10.24
105.54 ± 16.63
122.15 ± 26.10
140.97 ± 18.23▲
IL-17A
8.35 ± 3.91
3.70 ± 2.09
36.44 ± 30.49▲
29.68 ± 20.33
14.53 ± 4.73
19.65 ± 6.78
15.37 ± 3.42
30.52 ± 13.88▲
IL-18
136.57 ± 42.88
157.14 ± 85.53
471.45 ± 354.16
436.92 ± 374.40
640.50 ± 669.11▲
453.14 ± 383.18
214.26 ± 197.21
459.29 ± 305.39▲
MCP-1
855.72 ± 309.68
750.93 ± 219.38
7939.5 ± 5748.21
8296.6 ± 7103.81▲
5456.4 ± 2145.50
5685.4 ± 2610.89
7344.4 ± 2128.33
7420 ± 3687.26▲
IP-10
291.16 ± 76.83
241.01 ± 62.06
921.03 ± 458.42
979.95 ± 352.73▲
601.56 ± 241.94
867.48 ± 143.13▲
653.79 ± 180.21
822.54 ± 274.09
GRO/KC
12.23 ± 8.76
17.15 ± 6.99
16361 ± 14266.49▲
5538.8 ± 5664.49
3875 ± 3330.03
6199.4 ± 4313.97▲
4605.4 ± 2235.93
3894.75 ± 3154.25
VEGF
52.39 ± 21.31
52.0 ± 8.25
139.35 ± 111.78▲
97.94 ± 71.38
111.59 ± 93.36
94.86 ± 21.80
63.03 ± 21.77
106.72 ± 57.30▲
Fractalkine
80.86 ± 31.82
60.21 ± 10.99
131.05 ± 80.13
134.01 ± 135.06▲
73.80 ± 31.21
118.60 ± 40.96
69.76 ± 19.78
128.01 ± 75.52▲
LIX
2671 ± 172.81
2458.5 ± 347.71
3629.25 ± 859.08▲
3116.4 ± 983.28
3111.4 ± 1181.79
3815.6 ± 1137.01▲
3286.4 ± 796.47
3307.8 ± 796.00
MIP-2
91.92 ± 31.31
65.76 ± 16.40
5966 ± 3067.43▲
621.04 ± 280.54
371.54 ± 380.89
1844.39 ± 1099.42
840.10 ± 547.80
3875.67 ± 2332.24▲
TNF-α
8.76 ± 1.17
5.35 ± 3.98
46.40 ± 20.48▲
40.76 ± 48.68
13.26 ± 1.40
20.02 ± 5.13
25.33 ± 17.72
49.52 ± 38.76▲
RANTES
2235.8 ± 385.35
2161 ± 537.21
3981.25 ± 779.13▲
2488.4 ± 1003.48
2629.4 ± 876.18
3949 ± 1156.80▲
3259.2 ± 1015.13
2318.6 ± 1027.21
Serum concentrations of cytokines and chemokines were undetected if less than the minimum detectable concentration; ▲ represented the concentration peaks of cytokines and chemokines within 24 hours after surgery in CLP group and CLP+Cit group.
