Mitochondria Biogenesis and Bioenergetics Gene Profiles in Isogenic Prostate Cells with Different Malignant Phenotypes

Table 3

Top upstream regulators and target molecules in the regulatory network.

Upstream regulator	Molecule type	value of overlap	Target molecules in dataset
RBM5	Other		ATP5G3, CDKN2A, HSP90AA1, NDUFV2, UCP2
AIFM1	Enzyme		NDUFB6, NDUFS7
DEFB103A/DEFB103B	Other		BCL2L1, BID
BTG2	Transcription regulator		SOD1, SOD2
SHC1	Kinase		BAK1, BCL2L1
NFE2L2	Transcription regulator		SOD1, SOD2
APP	Other		DNM1L, HSPA1A/HSPA1B
RelB	Transcription regulator		BCL2L1, SOD2
HSF1	Transcription regulator		BCL2L1, HSP90AA1, HSPA1A/HSPA1B
SOCS1	Other		BAK1, BCL2L1
Igm	Complex		BAK1, CDKN2A
IGFBP7	Transporter		SOD2
NCF2	Enzyme		SOD2
mir-491	MicroRNA		BCL2L1
SIRPA	Phosphatase		BCL2L1
TERT	Enzyme		CDKN2A, SOD2
FAS	Transmembrane receptor		BID, SOD2
PPARA	Ligand-dependent nuclear receptor		CDKN2A, CPT2
IFNG	Cytokine		BAK1, BCL2L1, HSPA1A/HSPA1B, SOD2
LIN9	Other		CDKN2A
CASP3	Peptidase		BCL2L1
CUL4A	Other		SOD2
BTG3	Other		CDKN2A
NOXO1	Other		SOD2
CBX8	Other		CDKN2A
RAC2	Enzyme		BCL2L1
PRKACA	Kinase		CDKN2A
NEU2	Phosphatase		BCL2L1
S100A11	Kinase		HSPA1A/HSPA1B
BACH2	Enzyme		BCL2L1
CYBA	Other		CDKN2A
CFLAR	Transcription regulator		CDKN2A
NEU2	Enzyme		SOD2