Evaluation of Bone Metabolism in Critically Ill Patients Using CTx and PINP

Table 3

Demographics, admission diagnosis, and characteristics of the patients according to survival status (n = 28).

Variable	Survivors (n = 18)	Nonsurvivors (n = 10)	p
Age, (range) yrs	65.0 ± 2.5	71.6 ± 3.2	0.88
Males, n, %	10/18, 55.5%	6/10, 60.0%	1.0
Admission diagnosis, n
Pulmonary Infection, RR	10	5
Pulmonary edema, CHF	3	2
Complicated surgery	2	2
SAH/ICH	1	1
Abdominal sepsis	1
Trauma, head injury	1
Type, n
Medical	16	8
Surgical	2	2
APACHE II	21.9 ± 1.2	22.7 ± 1.5	0.58
SAPS II	62.9 ± 2.5	60.1 ± 3.5	0.83
SOFA	9.9 ± 0.9	10.5 ± 0.9	0.65
MV duration, days	14.3 ± 2.8	42.8 ± 11.7	0.039
ICU LOS (median), d	18.6 ± 2.9 (13)	55.0 ± 12.1 (51.5)	0.01
Fever, >38.2°C	8/18, 44,4%	4/10, 40%	1.0
Corrected calcium, mg/dL	7.9 ± 0.2	8.5 ± 0.6	0.65
Phosphorus, mg/dL	3.2 ± 0.3	3.8 ± 0.3	0.13
Alkaline phosphatase, mg/dL	117.7 ± 19.5	124.0 ± 17.1	0.18
Urea, mg/dL	54.5 ± 7.1	52.8 ± 8.3	0.96
AST (SGOT), IU/dL	51.4 ± 14.9	31.8 ± 4.6	1.0
ALT (SGPT), IU/dL	90.1 ± 44.4	31.1 ± 5.9	0.98
WBC, /mm^3	10,964 ± 1,997	11,309 ± 1,804	0.79
Creatinine, mg/dL	1.1 ± 0.8	1.2 ± 0.2	0.51
Albumin, g/dL	3.0 ± 0.1	3.3 ± 0.2	0.38
CRP, mg/dL	112.1 ± 24.2	97.8 ± 38.9	0.75
i-CTx (ng/mL)	0,96 ± 0,19	1,49 ± 0,32	0.098
P1NP (ng/mL)	15,46 ± 2,44	19,85 ± 5,34	0.773
i-PTH (pg/mL)	215,9 ± 39,68	159,6 ± 32,68	0.533
25-OH Vit. D (ng/mL)	6,45 ± 1,49	3,80 ± 0,94	0.433
Low-dose steroids, n	12/18	4/10
Shock, nor-adrenaline, n	17/18	10/10
LMWH, n	14/18	5/10
Fondaparinux (Arixtra), n	4/18	5/10
Transfusions, n, (mean)	10/18	8/10
Phenytoin (Epanutin), n	2/18	1/10
Food supplementation, n	18/18	10/10
Enteral	18/18	10/10
Parenteral	1/18	1/10
Both	1/18	1/10
Micronutrients	18/18	10/10
Vitamins	18/18	10/10

RR: respiratory failure, ICH: intracerebral hemorrhage, SAH: subarachnoid hemorrhage, CHF: congestive heart failure, LMWH: low molecular weight heparin, CRP: c-reactive protein, ICU: intensive care medicine, WBC: white blood cell, APACHE II: Acute Physiology And Chronic Health Evaluation, SOFA: Sequential Organ Failure Assessment, AST: Aspartate Aminotransferase, and ALT: Alanine Aminotransferase.