Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor

Figure 2

A comparison of amino acid substitutions due to nsSNPs. Two mutant structures of deleterious nsSNPs rs1051691 (I421T) (c) and rs121913156 (R1174Q) (d) were compared to their native structures 2HR7 (a) and 4IBM (b), respectively. Models were generated by using PYMOL and visualized by UCSF Chimera.

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