Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor

Figure 3

Superimposition of native and mutant structures. Native structure (2HR7) shows arginine at position 386 (a) and mutant modeled structure rs79312957 (R386C) shows cysteine residue at the corresponding position (b). (c) shows the superimposition of the native structure (red) with mutant modeled structure (green) in position 386.

(a)

(b)

(c)